| VFL/AFL | AFLW | |||
VFL/AFL
| Player | MFC games | MFC goals | Years | |
| Tom Sadlier | 1 | 0 | 1910 | |
| Christian Salem | * | * | 2014- | |
| Alex Salvado | 5 | 2 | 1919 | |
| Lou Salvana | 6 | 3 | 1919 | |
| Jack Sambell | 24 | 6 | 1933-1934 | |
| Clay Sampson | 13 | 1 | 1995-1996 | |
| Ray Sampson | 1 | 0 | 1969 | |
| Jim Sandral | 22 | 2 | 1956-1957 | |
| Bill Scanlan | 51 | 22 | 1943-1948 | |
| Frank Scanlan | 33 | 13 | 1943-1944, 1947-1948 | |
| Pat Scanlan | 6 | 2 | 1898-1899 | |
| Josh Schache | 4 | 1 | 2023-2024 | |
| Peter Schofield | 6 | 14 | 1953 | |
| Darryl Schwarz | 12 | 0 | 1968-1969 | |
| David Schwarz | 173 | 243 | 1991-1995, 1997-2002 | |
| Graham Scott | 8 | 4 | 1974 | |
| Tom Scully | 31 | 6 | 2010-2011 | |
| Phil Seaton | 19 | 5 | 1978-1980 | |
| Michael Seddon | 57 | 24 | 1980-1983 | |
| Marcus Seecamp | 89 | 8 | 1995-2000 | |
| James Sellar | 23 | 11 | 2012-2013 | |
| Ike Sellers | 2 | 0 | 1932 | |
| Harry Selover | 3 | 2 | 1919 | |
| Dannie Seow | 7 | 2 | 1989-1990 | |
| Ken Shadbolt | 2 | 0 | 1943 | |
| Ralph Shalless | 4 | 3 | 1943, 1946 | |
| Jamie Shanahan | 37 | 0 | 1998-1999 | |
| Billy Shaw | 1 | 0 | 1901 | |
| Eddie Shaw | 1 | 0 | 1927 | |
| Jim Shaw | 3 | 2 | 1949 | |
| Fred Sheahan | 16 | 0 | 1897 | |
| Gerald Sheahan | 1 | 0 | 1897 | |
| Ray Shearer | 2 | 0 | 1942 | |
| Bill Shelton | 54 | 17 | 1919-1925 | |
| Ben Sheppard | 4 | 1 | 1911 | |
| Eddie Sholl | 50 | 2 | 1897-1902 | |
| Scott Simister | 3 | 2 | 1993 | |
| George Simmonds | 4 | 4 | 1924 | |
| Troy Simmonds | 40 | 7 | 1999-2001 | |
| Arthur Sinclair | 1 | 0 | 1899 | |
| Peter Sinclair | 34 | 18 | 1969-1972 | |
| Greg Sizer | 1 | 1 | 1986 | |
| Peter Slade | 15 | 4 | 1974 | |
| Fred Sleeman | 14 | 4 | 1906 | |
| Lance Sleeman | 1 | 0 | 1906 | |
| Lionel Smale | 2 | 0 | 1904 | |
| Bill Smeaton | 17 | 33 | 1951-1952 | |
| Frank Smith | 14 | 0 | 1931-1932 | |
| Henry Smith | 1 | 0 | 1906 | |
| Jack Smith | 51 | 27 | 1907-1909, 1911 | |
| Joel Smith | * | * | 2017-2018, 2020- | |
| Kim Smith | 4 | 3 | 1975 | |
| Len Smith | 19 | 3 | 1934-1935 | |
| Les Smith | 7 | 1 | 1914 | |
| Nick Smith | 4 | 0 | 2003, 2006 | |
| Norm Smith | 210 | 546 | 1935-1948 | |
| Peter Smith | 23 | 23 | 1966-1967 | |
| Ray Smith | 27 | 1 | 1975-1976 | |
| Shaun Smith | 62 | 96 | 1995-1998 | |
| Steven Smith | 203 | 144 | 1974-1985 | |
| Tim Smith | 13 | 11 | 2017-2019 | |
| Craig Smoker | 17 | 12 | 1998-1999 | |
| Arthur Sowden | 117 | 13 | 1899-1906 | |
| Earl Spalding | 109 | 63 | 1987-1991 | |
| Bob Spargo | 2 | 0 | 1942 | |
| Charlie Spargo | * | * | 2018- | |
| Brad Sparks | 4 | 4 | 1987-1988 | |
| John Sparks | 9 | 8 | 1975, 1977 | |
| Tom Sparrow | * | * | 2019- | |
| Jake Spencer | 38 | 8 | 2009-2010, 2012-2015, 2017 | |
| Stuart Spencer | 122 | 146 | 1950-1956 | |
| Trevor Spencer | 3 | 0 | 1990-1991 | |
| Max Spittle | 50 | 1 | 1947-1950 | |
| George St John | 1 | 0 | 1911 | |
| Roy Stabb | 29 | 2 | 1945-1947 | |
| Frank Staines | 5 | 0 | 1898 | |
| Harold Stanley | 1 | 1 | 1906 | |
| Clyde Stanway | 13 | 1 | 1906 | |
| Howard Steel | 9 | 3 | 1930-1932 | |
| Cyril Steele | 3 | 0 | 1910 | |
| Wally Steele | 26 | 12 | 1897-1898 | |
| Norm Stephenson | 1 | 0 | 1906 | |
| Robert Stewart | 17 | 0 | 1966-1967 | |
| Jack Stock | 14 | 0 | 1944-1945 | |
| Bob Stone | 8 | 0 | 1942-1943, 1949 | |
| Neville Stone | 35 | 19 | 1966-1969 | |
| Dave Strahan | 29 | 0 | 1897-1900 | |
| James Strauss | 24 | 1 | 2010-2013 | |
| Charlie Streeter | 133 | 10 | 1920-1928 | |
| Percy Streeter | 2 | 0 | 1933 | |
| Billy Stretch | 47 | 10 | 2015-2019 | |
| Steven Stretch | 164 | 71 | 1986-1993 | |
| Jack Strong | 78 | 29 | 1901, 1903-1910, 1912 | |
| Brian Stynes | 2 | 0 | 1992 | |
| Jim Stynes | 264 | 130 | 1987-1998 | |
| Charles Suhr | 1 | 0 | 1906 | |
| Chris Sullivan | 27 | 22 | 1992, 1994 | |
| Jimmy Sullivan | 6 | 0 | 1925 | |
| Tony Sullivan | 191 | 1 | 1967-1979 | |
| Scott Sutcliffe | 7 | 2 | 1982-1983 | |
| Ned Sutton | 32 | 0 | 1897-1898 | |
| Glenn Swan | 13 | 21 | 1973 | |
| Bill Sweeney | 4 | 3 | 1934-1935 | |
| Wally Sykes | 41 | 17 | 1907-1912 | |
| Colin Sylvia | 157 | 129 | 2004-2013 | |
| Derek Symonds | 1 | 0 | 1939 | |
| Herb Symonds | 4 | 3 | 1907 | |
AFLW
| Player | MFC games | MFC goals | Years | Also played for |
| Shelley Scott | 49 | 26 | 2017-2022 summer | Geelong |
| Casey Sherriff | 48 | 9 | 2020-2023 | Hawthorn |
| Shae Sloane | 1 | 0 | 2019 | |
| Katherine Smith | 21 | 2 | 2017-2019 | Greater Western Sydney |
| Elise Strachan | 1 | 0 | 2017 | |