Coach - Michael Stinear
Captain - Daisy Pearce
Finishing Position: 2nd (Premiers)
Best and Fairest - Kate Hore
Leading Goalkicker - Kate Hore (17)
Major Sponsors: Hertz/Zurich
Members: 3361
A second season was played in 2022 to realign the competition's calendar to play AFLW in Spring. Daisy Pearce continued as captain, while Kate Hore was elevated to vice-captain.
Melbourne only lost one home and away game, failing to capture the minor premiership by the narrowest possible margin. They would have passed Brisbane by scoring one more point in the Round 10 game against West Coast but ran out of time and missed top spot by 0.2%.
Melbourne qualified for another Grand Final, beating Brisbane Lions in the first game played at Springfield to capture their maiden women's premiership.
At the end of the season a special signing period allowed recent expansion sides to recruit contracted players. No Melbourne player left the club during this time.
Practice matches
| Opposition | Result | Score | |||
| Essendon | WIN | 84-40 | |||
| Carlton | WIN | 86-16 | |||
Premiership season
| Round | Opposition | Result | Score | ||
| 1 | Adelaide | WIN | 44-26 | ||
| 2 | North Melbourne | WIN | 26-24 | ||
| 3 | St Kilda | WIN | 46-20 | ||
| 4 | Brisbane Lions | LOSS | 27-42 | ||
| 5 | Carlton | WIN | 50-8 | ||
| 6 | Fremantle | WIN | 66-36 | ||
| 7 | Western Bulldogs | WIN | 73-9 | ||
| 8 | Gold Coast | WIN | 58-9 | ||
| 9 | Essendon | WIN | 50-9 | ||
| 10 | West Coast | WIN | 79-1 | ||
| QF | Adelaide | WIN | 48-27 | ||
| PF | North Melbourne | WIN | 33-16 | ||
| GF | Brisbane Lions | WIN | 19-15 | ||
Playing list
| Number | Player | Games | Goals | ||
| 1 | Georgia Campbell | 1 | 0 | ||
| 2 | Olivia Purcell | 13 | 3 | ||
| 3 | Maddie Gay | 9 | 0 | ||
| 4 | Karen Paxman | 13 | 5 | ||
| 5 | Tyla Hanks | 13 | 3 | ||
| 6 | Daisy Pearce | 13 | 6 | ||
| 7 | Tayla Harris | 12 | 11 | ||
| 8 | Sarah Lampard | 13 | 2 | ||
| 9 | Libby Birch | 13 | 0 | ||
| 10 | Kate Hore | 13 | 17 | ||
| 11 | Eliza West | 13 | 1 | ||
| 12 | Sabreena Duffy | 4 | 4 | ||
| 13 | Maeve Chaplin | 12 | 0 | ||
| 14 | Lily Mithen | 13 | 1 | ||
| 15 | Lauren Pearce | 12 | 2 | ||
| 16 | Alyssa Bannan | 13 | 10 | ||
| 17 | Tahlia Gillard | 13 | 0 | ||
| 18 | Casey Sherriff | 11 | 1 | ||
| 19 | Jordan Ivey | 3 | 0 | ||
| 20 | Charlotte Wilson | 4 | 0 | ||
| 21 | Maggie Caris | 1 | 0 | ||
| 22 | Eliza McNamara | 0 | 0 | ||
| 23 | Sinead Goldrick | 8 | 0 | ||
| 24 | Megan Fitzsimon | 13 | 4 | ||
| 25 | Samantha Johnson | 3 | 0 | ||
| 26 | Rhiannon Watt | 0 | 0 | ||
| 27 | Georgia Gall | 0 | 0 | ||
| 28 | Ali Brown | 1 | 0 | ||
| 29 | Eden Zanker | 13 | 14 | ||
| 30 | Shelley Heath | 13 | 1 | ||
| 31 | Blaithin Mackin | 10 | 2 | ||
| 32 | Gabrielle Colvin | 0 | 0 | ||
| 33 | Ella Little | 0 | 0 | ||
| 34 | Melanie Hogg | 0 | 0 | ||
| 35 | Belinda Woolcock | 0 | 0 | ||
Ladder
| W | D | L | % | P | |
| Brisbane Lions | 9 | 0 | 1 | 282.4 | 36 |
| Melbourne | 9 | 0 | 1 | 282.1 | 36 |
| Adelaide | 8 | 0 | 2 | 177.6 | 32 |
| Richmond | 7 | 1 | 2 | 147.9 | 30 |
| Geelong | 7 | 0 | 3 | 173.0 | 28 |
| Collingwood | 7 | 0 | 3 | 118.4 | 28 |
| Western Bulldogs | 7 | 0 | 3 | 109.8 | 28 |
| North Melbourne | 6 | 1 | 3 | 166.8 | 26 |
| Gold Coast | 5 | 0 | 5 | 88.0 | 20 |
| Essendon | 4 | 0 | 6 | 98.6 | 16 |
| Greater Western Sydney | 4 | 0 | 6 | 63.1 | 16 |
| Fremantle | 3 | 1 | 6 | 66.8 | 14 |
| St Kilda | 3 | 0 | 7 | 82.3 | 12 |
| Carlton | 2 | 2 | 6 | 74 | 12 |
| Hawthorn | 3 | 0 | 7 | 57.1 | 12 |
| West Coast | 2 | 0 | 8 | 53.2 | 8 |
| Port Adelaide | 1 | 1 | 8 | 70.6 | 6 |
| Sydney | 0 | 0 | 10 | 35.9 | 0 |
Club best and Fairest
| Player | Votes | ||||
| 1st | Kate Hore | 69 | |||
| 2nd | Tyla Hanks | 64 | |||
| 3rd | Olivia Purcell | 61 | |||
| 4th | Lily Mithen | 60 | |||
| 5th | Karen Paxman Tayla Harris Shelley Heath | 56 | |||
| 8th | Libby Birch Eliza West | 55 | |||
| 10th | Sarah Lampard | 53 | |||
Other awards
Demon Spirit award - Rhiannon Watt
AFL Best and Fairest
| Player | Votes | ||||
| Olivia Purcell | 16 | ||||
| Karen Paxman Tayla Harris | 7 | ||||
| Eliza West | 6 | ||||
| Kate Hore | 5 | ||||
| Lauren Pearce Tyla Hanks | 2 | ||||
| Daisy Pearce Lily Mithen Alyssa Bannan | 1 | ||||
Coaches votes
| Player | Votes | ||||
| Kate Hore | 41 | ||||
| Olivia Purcell | 38 | ||||
| Eliza West | 34 | ||||
| Tayla Harris | 24 | ||||
| Karen Paxman | 19 | ||||
| Tyla Hanks | 18 | ||||
| Lily Mithen | 14 | ||||
| Libby Birch | 12 | ||||
| Shelley Heath | 10 | ||||
| Maddie Gay | 9 | ||||
| Lauren Pearce | 8 | ||||
| Sarah Lampard | 5 | ||||
| Alyssa Bannan | 2 | ||||
Tribunal
| Round | Player | Charge | Sanction | ||
| Round 3 | Tayla Harris | Dangerous tackle | 1 week | ||
| Round 3 | Tayla Harris | Rough conduct | 1 week | ||
| Round 10 | Tayla Harris | Forceful front-on contact | $400 fine | ||
| Round 10 | Shelley Heath | Dangerous tackle | $400 fine | ||
| Qualifying Final | Tahlia Gillard | Rough conduct - tackle | $400 fine | ||
Coaching staff
Dale Amos - Head of Midfield/Technical Coach
Matt Brewer - Assistant Coach - Midfield
Ben Brown - Specialist coach/Mentor
Vincent Chungue - Strategy and Opposition
Tamara Hyett - Assistant Coach - Backs
Jane Lange - Senior Assistant Coach - Education and Game Style
Shae Sloane - Assistant Coach - Forwards
Jon Stinear - Development coach - runner