| Goals | Player | Match |
| 6 | Harry Davie | Round 16, 1924 vs Richmond at Punt Road |
| 5 | Tommy Ryan | Round 1, 1899 vs St Kilda at MCG |
| 5 | George Cathie | Round 16, 1901 vs St Kilda at Lake Oval |
| 5 | Campbell Brady | Round 2, 1913 vs University at MCG |
| 5 | Harry Harker | Round 2, 1920 vs Essendon at East Melbourne |
| 5 | Bob McKenzie | Round 1, 1948 vs Essendon at MCG |
| 5 | Brent Heaver | Round 11, 1990 vs Carlton at MCG |
| 5 | Sean Charles | Round 10, 1992 vs North Melbourne at MCG |
Four goal debuts (incomplete)
| Player | Match | |
| Johnny Hassett | Round 12, 1913 vs Carlton at MCG | |
| Jack Mueller | Round 1, 1934 vs Richmond at Punt Road | |
| Robert B Johnson | Round 11, 1954 vs North Melbourne at MCG | |
| Greg Wells | Round 18, 1969 vs Carlton at MCG | |
| Marty Lyons | Round 1, 1975 vs Footscray at MCG | |
| Henry McCrae | Round 1, 1929 vs South Melbourne at MCG | |
| Russell Rowe | Round 1, 1980 vs St Kilda at Waverley | |
| Mark Jackson | Round 1, 1981 vs Hawthorn at MCG | |
| John Fidge | Round 4, 1984 vs Essendon at Waverley | |