Round 4, 2022
Port Adelaide vs Melbourne
Thursday 7 April
Venue: Adelaide Oval
Attendance: 23,058
| 1st | 2nd | 3rd | Final | |
| Port Adelaide | 0.3 | 0.5 | 1.8 | 4.12.36 |
| Melbourne | 1.3 | 6.6 | 9.7 | 10.8.68 |
Melbourne win by 32 points
Goalkickers: Bayley Fritsch 3, James Harmes 2, Max Gawn 1, Luke Jackson 1, Ed Langdon 1, Tom McDonald 1, Jack Viney 1
Milestones:
Nil
The Demons finished the first month of the new season without a loss, holding Port Adelaide goalless in the first half for their first time as an AFL club. A five goal to nil second quarter set up a match-winning lead, and only late consolation goals by the Power made the score respectable.
Best were Gawn, Harmes and Jackson. Toby Bedford was an unused substitute.