Mid-Season draft
| Pick | Player | From | Games |
| 15 | Kye Declase | Werribee | 0 |
| 24 | Daniel Turner | Murray Bushrangers/Albury | * |
Trades
| Received | From | Exchanged | |
| 2021 National Draft selection #17 2021 National Draft selection #37 2021 National Draft selection #49 | Western Bulldogs Adelaide St Kilda | 2021 National Draft selection #33 (to Adelaide) 2022 National Draft second round selection (to Adelaide) | |
| 2022 National Draft third round selection | Adelaide | 2021 National Draft selection #43 | |
| 2022 National Draft fourth round selection | St Kilda | 2021 National Draft selection #51 | |
National Draft
Wednesday 24 November (first round) and Thursday 25 November (subsequent rounds). Melbourne made trades with Adelaide and St Kilda during the second night of the draft.
| Pick | Player | From | Games |
| 19 | Jacob van Rooyen | Claremont | * |
| 39 | Blake Howes | Sandringham Dragons | * |
| 65 | Taj Woewodin (f/s) | East Fremantle | * |
Rookie Draft
Friday 26 November
| Pick | Player | From | Games |
| 18 | Judd McVee | East Fremantle | * |