VFL/AFL
Melbourne has failed to score in the opening quarter of a VFL/AFL match on 16 occasions. Four times they have survived to win the match.
For Melbourne
| Round | Opponent | Final Score | Venue | Result |
| Round 14, 1898 | Geelong | 19 | Corio Oval | LOSS |
| Round 7, 1899 | South Melbourne | 50 | MCG | WIN |
| Round 16, 1899 | Fitzroy | 2 | Brunswick Street | LOSS |
| Round 6, 1903 | St. Kilda | 27 | Junction Oval | LOSS |
| Round 8, 1905 | St. Kilda | 51 | Junction Oval | LOSS |
| Round 15, 1906 | Fitzroy | 13 | MCG | LOSS |
| Round 9, 1908 | Fitzroy | 28 | MCG | WIN |
| Round 5, 1912 | Carlton | 50 | MCG | WIN |
| Round 15, 1913 | South Melbourne | 19 | MCG | LOSS |
| Round 15, 1924 | Geelong | 39 | MCG | LOSS |
| Round 10, 1942 | Carlton | 67 | Princes Park | LOSS |
| Round 9, 1953 | Collingwood | 48 | MCG | LOSS |
| Round 15, 1968 | North Melbourne | 40 | Arden Street | WIN |
| Round 1, 1991 | West Coast | 20 | Subiaco | LOSS |
| Round 19, 2008 | Geelong | 41 | MCG | LOSS |
| Round 9, 2024 | Carlton | 76 | MCG | LOSS |
Venues
9 - MCG
2 - Junction Oval
1 - Corio Oval, Brunswick Street, Princes Park, Arden Street, Subiaco
Opponents
3 - Carlton, Fitzroy, Geelong
2 - St Kilda, South Melbourne
1 - Collingwood, North Melbourne, West Coast
Coaches (1907 onwards. No senior coach in 1911)
2 - Alex Hall
1 - Gordon Rattray, Percy Beames 1, Norm Smith 1, John Beckwith 1, John Northey 1, Dean Bailey 1
Against Melbourne
Melbourne has held an opposition side scoreless in the first quarter 25 times, for 19 wins, one draw and five losses.
Venues
13 - MCG
4 - Junction Oval, Western Oval
2 - Arden Street
1 - Brunswick Street, Docklands, East Melbourne, Waverley
Opponents
8 - St Kilda
4 - Carlton, Footscray
3 - Geelong
2 - Collingwood, Essendon, North Melbourne
1 - Fitzroy, Hawthorn
Coaches
6 - Norm Smith
2 - Alex Hall, Checker Hughes, Allan La Fontaine, Ivor Warne-Smith
1 - Neale Balme, Simon Goodwin, Ian Ridley, John Northey
Notes
Round 2, 2020 was played with 16 minute quarters.
AFLW
For Melbourne
| Round | Opponent | Final Score | Venue | Result |
| Round 6, 2017 | Adelaide | 8-68 | Casey Fields | LOST |
| Round 7, 2019 | Adelaide | Docklands | 39-38 | WON |
| Round 1, 2020 | North Melbourne | Casey Fields | 22-20 | WON |
| Round 7, 2022 | Brisbane Lions | 35-32 | Carrara | WON |
| Preliminary Final 2022 | Brisbane Lions | 33-29 | WON | |
| Grand Final 2022 | Adelaide | 16-29 | LOSS | |
Against Melbourne
| Round | Opponent | Final Score | Venue | Result |
| Round 1, 2017 | Brisbane Lions | Casey Fields | 10-25 | LOST |
| Round 3, 2018 | Fremantle | Fremantle Oval | 31-36 | LOST |
| Round 4, 2018 | Collingwood | Traeger Park | 24-58 | LOST |
| Round 5, 2018 | Brisbane Lions | Casey Fields | 34-28 | WON |
| Round 7, 2018 | Western Bulldogs | Western Oval | 31-33 | LOST |
| Round 6, 2019 | Western Bulldogs | Docklands | 39-38 | WON |
| Round 5, 2020 | West Coast | Casey Fields | 66-7 | WON |
| Round 6, 2021 | St Kilda | Casey Fields | 66-22 | WON |
| Round 10, 2022 summer season | Carlton | Casey Fields | 34-33 | WON |
| Round 3, 2022 spring season | St Kilda | Moorabbin | 46-20 | WON |
| Round 7, 2022 spring season | Western Bulldogs | Casey Fields | 73-9 | WON |
| Round 7, 2022 spring season | Western Bulldogs | Casey Fields | 73-9 | WON |
| Round 8, 2022 spring season | Gold Coast | Carrara | 58-9 | WON |
| Round 9, 2022 spring season | Essendon | Casey Fields | 50-9 | WON |
| Round 10, 2022 spring season | West Coast | Casey Fields | 79-1 | WON |
| Round 6, 2023 | Adelaide | Casey Fields | WIN | |