Melbourne has won 15 matches by over 100 points between 1901 and 2018.

See also: Highest Scores and 100 point losses

	Margin	Opponent	Round	Venue
1	141	Hawthorn	Round 9, 1926	MCG
2	131	Fitzroy	Round 2, 1991	Princes Park
3	122	North Melbourne	Round 7, 1937	MCG
4	121	Richmond	Round 21, 1993	MCG
5	118	North Melbourne	Elimination Final 1987	MCG
6	114	Hawthorn	Round 17, 1940	MCG
7	113	Richmond	Round 10, 1964	MCG
8	109	Carlton	Round 9, 2018	MCG
9	108	North Melbourne	Round 10, 1972	Arden Street
10	107	South Melbourne	Round 6, 1939	MCG
11	105	Hawthorn	Round 11, 1944	Glenferrie Oval
11	105	St. Kilda	Round 13, 1948	MCG
11	105	South Melbourne	Round 1, 1971	MCG
11	105	Carlton	Round 6, 2004	MCG
15	102	St. Kilda	Round 16, 1901	Lake Oval

Opponents
3 - Hawthorn
2 - St Kilda, South Melbourne, Richmond, Carlton
1 - Fitzroy

Coaches
4 - Checker Hughes
2 - John Northey
2 - Ian Ridley
1 - Bert Chadwick, Percy Beames, Norm Smith, Ian Ridley, Neale Balme, Neale Daniher, Simon Goodwin

Debuts in 100 point wins

Player	Game	Margin
George Cathie	Round 16, 1901	102
Fred Dick	Round 9, 1926	141
Keith Truscott	Round 7, 1937	122
Darren Cuthbertson	Round 2, 1991	131
Adrian Dullard	Round 17, 1940	114
Noel Ellis	Round 17, 1940	114
John Gallus	Round 1, 1971	105
Col Anderson	Round 10, 1972	108

Other Top 50 wins

	Margin	Opponent	Round	Venue
16	98	Gold Coast	Round 20, 2021	Docklands
17	97	St Kilda	Round 12, 1955	MCG
17	97	Sydney	Round 12, 1984	MCG
19	96	Hawthorn	Round 18, 1950	MCG
19	96	Fitzroy	Round 15, 1963	Brunswick Street
19	96	Adelaide	Round 7, 2011	MCG
19	96	Gold Coast	Round 20, 2018	MCG
23	95	Brisbane Lions	Round 18, 1998	MCG
24	94	Collingwood	Round 10, 1939	MCG
25	93	St Kilda	Round 1, 1899	MCG
25	93	St Kilda	Round 19, 1947	Junction Oval
25	93	Richmond	Round 6, 1993	MCG
28	92	Richmond	Round 6, 1960	MCG
28	92	Hawthorn	Round 13, 1966	MCG
30	90	Essendon	Round 15, 1927	MCG
30	90	St Kilda	Round 4, 2000	MCG
30	90	Gold Coast	Round 4, 2011	Gabba
33	89	St Kilda	Round 12, 1926	Junction Oval
33	89	Hawthorn	Round 2, 1934	MCG
33	89	Collingwood	Semi Final 1964	MCG
33	89	Brisbane Bears	Round 18, 1993	MCG
33	89	Fremantle	Round 13, 2011	MCG
38	87	North Melbourne	Round 18, 1928	MCG
38	87	Brisbane Bears	Round 5, 1994	MCG
40	85	Essendon	Round 2, 1937	Windy Hill
40	85	North Melbourne	Round 21, 1986	MCG
42	84	North Melbourne	Round 7, 1927	MCG
42	84	Fitzroy	Round 12, 1957	MCG
44	83	Sydney	Round 15, 1991	SCG
44	83	Fremantle	Round 20, 2000	Docklands
44	83	Geelong	Preliminary Final 2021	Perth Stadium
47	82	North Melbourne	Round 11, 1959	MCG
48	81	Carlton	Round 5, 1897	MCG
49	81	Fitzroy	Round 15, 1995	Western Oval
50	80	Footscray	Round 12, 1943	Punt Road
49	79	St Kilda	Round 8, 1900	MCG
49	79	Geelong	Round 7, 1909	MCG
49	79	Richmond	Round 6, 1963	MCG
49	79	Footscray	Semi Final 1994	MCG