Years: 1925 -
Home grounds: Glenferrie Oval, Princes Park, Waverley, MCG
First VFL/AFL game: Round 11, 1925 at Glenferrie Oval
| Wins | Draws | Losses | % |
| 83 | 1 | 87 | 48.53 |
One of three VFA clubs to join the VFL in 1925, Hawthorn were easybeats of the competition in their early years but Melbourne would often have trouble playing on their narrow Glenferrie Oval ground.
Melbourne's largest ever win was recorded against Hawthorn in Round 9, 1926.
The Hawks beat Melbourne in the 1987 Preliminary Final with a kick after the siren, and the 1988 Grand Final by a then-record margin.
In 1996 a merger was proposed between the clubs, ultimately defeated by the votes of Hawks members.
Biggest win
| Margin | Round | Venue | |
| 1 | 141 | Round 9, 1926 | MCG |
| 2 | 114 | Round 17, 1940 | MCG |
| 3 | 105 | Round 11, 1944 | Glenferrie Oval |
| 4 | 96 | Round 18, 1950 | MCG |
| 5 | 92 | Round 13, 1966 | MCG |
| 6 | 89 | Round 2, 1934 | MCG |
| 7 | 77 | Round 14, 1954 | MCG |
| 8 | 75 | Round 15, 1931 | MCG |
| 8 | 75 | Round 8, 2006 | MCG |
| 10 | 69 | Round 15, 2000 | MCG |
Highest score
| Score | Round | Venue | |
| 1 | 26.20.176 | Round 17, 1940 | MCG |
| 2 | 22.25.157 | Round 11, 1944 | Glenferrie Oval |
| 3 | 23.18.156 | Round 18, 1950 | MCG |
| 4 | 21.28.154 | Round 9, 1926 | MCG |
| 5 | 23.13.151 | Round 13, 1966 | MCG |
| 6 | 22.12.144 | Preliminary Final 1957 | MCG |
| 7 | 22.9.141 | Round 15, 2000 | MCG |
| 8 | 21.10.136 | Round 11, 1933 | MCG |
| 8 | 20.16.136 | Round 8, 2006 | MCG |
| 10 | 20.13.133 | Round 2, 1934 | MCG |
Biggest loss
| Margin | Round | Venue | |
| 1 | 115 | Round 21, 1983 | Waverley |
| 2 | 105 | Round 7, 2015 | MCG |
| 3 | 104 | Round 1, 2008 | MCG |
| 4 | 96 | Grand Final 1988 | MCG |
| 5 | 95 | Round 10, 2013 | MCG |
| 6 | 85 | Round 11, 1986 | Princes Park |
| 6 | 85 | Round 19, 2001 | MCG |
| 8 | 79 | Round 1, 1978 | Princes Park |
| 8 | 79 | Round 11, 1982 | Princes Park |
| 10 | 77 | Round 19, 1980 | MCG |
Lowest score
| Score | Round | Venue | |
| 1 | 3.11.29 | Round 2, 1966 | Glenferrie Oval |
| 2 | 4.9.33 | Round 4, 1957 | Glenferrie Oval |
| 3 | 5.10.40 | Round 13, 1961 | Glenferrie Oval |
| 4 | 5.14.44 | Round 4, 2001 | MCG |
| 4 | 5.14.44 | Round 2, 1961 | MCG |
| 6 | 7.6.48 | Round 9, 1992 | Waverley |
| 6 | 7.6.48 | Round 9, 1990 | Waverley |
| 6 | 6.12.48 | Round 4, 2018 | MCG |
| 6 | 6.12.48 | Round 10, 2013 | MCG |
| 10 | 6.13.49 | Round 7, 2012 | MCG |
Lowest score (1980-)
| Score | Round | Venue | |
| 1 | 5.14.44 | Round 4, 2001 | MCG |
| 2 | 7.6.48 | Round 9, 1990 | Waverley |
| 2 | 7.6.48 | Round 9, 1992 | Waverley |
| 2 | 6.12.48 | Round 10, 2013 | MCG |
| 2 | 6.12.48 | Round 4, 2018 | MCG |
| 6 | 6.13.49 | Round 7, 2012 | MCG |
| 7 | 7.8.50 | Round 7, 2015 | MCG |
| 7 | 6.14.50 | Round 16, 1986 | Waverley |
| 7 | 6.14.50 | Round 1, 2008 | MCG |
| 10 | 8.6.54 | Round 19, 1999 | Waverley |
Shared players
1920s
Dave Elliman
Clarrie Lethlean
Jack Pickford
1930s
Bert Chandler
Bill Deague
Ken Feltscheer
Lew Gough
Les Meade
Jack Pickford
1940s
Tom Ferguson
Bob Herbert
Keith Molloy
Jack O'Keefe
Ralph Shalless
1950s
1960s
1980s
Michael Byrne
Roger Ellingworth
David Flintoff
2010s
Cameron Bruce
Kyle Cheney
Jack Fitzpatrick
James Frawley
Paul Johnson
Jordan Lewis
Tom Scully
2020s
AFLW
First game: 2023 practice match at Casey Fields
First AFLW game: Round 4, 2023 at Frankston Oval
Biggest win
| Margin | Round | Venue | |
| 1 | 59 | Round 4, 2023 | Frankston Oval |
Highest score
| Score | Round | Venue | |
| 1 | 10.10.70 | Round 4, 2023 | Frankston Oval |
Shared players
2020s
Tegan Cunningham
Sarah Perkins
Casey Sherriff
Eliza West