Captain - Coach: Percy Wilson
Finishing Position: 6th
Best and Fairest: n/a
Leading Goalkicker: Harry Harker (47)
Best First Year Player: n/a
Members: 397
| Matches | Ladder | Playing list | |||
After unsuccessfully trying to appoint Percy Wilson of Collingwood as captain/coach a year earlier, they got their man and after one season in charge Gerald Brosnan became Supervisor of Umpires for the VFL. After falling apart in the second half of 1920, Wilson's side started the year badly before recovering to finish two games outside the top four. The season started against the backdrop of off-field turmoil, with two factions vying for control of the club. The incumbent committee was challenged by a reform group of HD Westley, C. Finlay, K. Batten, C. Brady, H. Ritchie and GH Watson, with a G. Strickland as an independent candidate. Andrew Manzie and Bill McClelland were Melbourne's delegates to the league.
St Kilda protested the Round 5 draw, claiming Melbourne had incorrectly been given a point but the result stood.
Melbourne was scheduled to play a game in Colac during July but pulled out in the week of the game.
This was the first season where scores from other grounds were displayed, with codes to decipher the scores available in the Football Record.
A player's cricket team began play in the Metropolitan League competition over the 1921/1922 summer.
Practice match
| Opposition | Result | Score | |||
| Melbourne Juniors | ? | ? | |||
Premiership Season
| Round | Opposition | Result | Score | ||
| 1 | Essendon | DRAW | 78-78 | ||
| 2 | Collingwood | LOSS | 53-94 | ||
| 3 | BYE | ||||
| 4 | South Melbourne | WIN | 70-69 | ||
| 5 | St. Kilda | DRAW | 90-90 | ||
| 6 | Richmond | LOSS | 92-95 | ||
| 7 | Fitzroy | WIN | 69-41 | ||
| 8 | Carlton | LOSS | 55-62 | ||
| 9 | Geelong | LOSS | 64-76 | ||
| 10 | Essendon | LOSS | 54-80 | ||
| 11 | Collingwood | WIN | 49-32 | ||
| 12 | BYE | ||||
| 13 | South Melbourne | LOSS | 53-69 | ||
| 14 | St. Kilda | WIN | 56-49 | ||
| 15 | Richmond | LOSS | 59-78 | ||
| 16 | Fitzroy | WIN | 63-62 | ||
| 17 | Carlton | LOSS | 76-100 | ||
| 18 | Geelong | WIN | 115-71 | ||
Ladder
| W | D | L | % | P | |
| Carlton | 13 | 2 | 1 | 142.0 | 56 |
| Richmond | 12 | 0 | 4 | 116.1 | 48 |
| Collingwood | 9 | 0 | 7 | 111.9 | 36 |
| Geelong | 9 | 0 | 7 | 106.1 | 36 |
| Fitzroy | 6 | 2 | 8 | 103.9 | 28 |
| Melbourne | 6 | 2 | 8 | 95.4 | 28 |
| South Melbourne | 5 | 1 | 10 | 84.6 | 22 |
| St. Kilda | 4 | 1 | 11 | 77.1 | 18 |
| Essendon | 3 | 2 | 11 | 80.8 | 16 |
Playing list
| Number | Player | Games | Goals | ||
| 1 | Bill Allen | 14 | 5 | ||
| 2 | Joe Flanagan | 8 | 0 | ||
| 3 | Ted Thomas | 12 | 1 | ||
| 4 | Francis Lyon | 1 | 0 | ||
| 5 | Harry Harker | 16 | 47 | ||
| 6 | Herb Matthews | 13 | 6 | ||
| 7 | Mick Anthony | 8 | 0 | ||
| 8 | Charlie Lilley | 13 | 0 | ||
| 9 | Charlie Streeter | 15 | 0 | ||
| 10 | Jack Brake | 3 | 1 | ||
| 11 | John Lord | 14 | 7 | ||
| 12 | Bob Corbett | 6 | 0 | ||
| 13 | Bill Shelton | 2 | 2 | ||
| 14 | Alec Gray | 1 | 0 | ||
| 15 | George Haines | 16 | 22 | ||
| 16 | Clarrie Lethlean | 9 | 0 | ||
| 17 | Bert Chadwick | 15 | 9 | ||
| 18 | Percy Tulloh | 15 | 18 | ||
| 19 | Harry Coy | 15 | 0 | ||
| 20 | Alf Wilson | 8 | 3 | ||
| 20 | George Walker | 1 | 0 | ||
| 21 | Jack House | 14 | 9 | ||
| 22 | Harry Bruce | 7 | 1 | ||
| 23 | Les Boyd | 7 | 1 | ||
| 25 | Percy Wilson | 16 | 8 | ||
| 26 | Enos Thomas | 2 | 1 | ||
| 27 | Bill Lyte | 1 | 0 | ||
| 28 | Alec Farrow | 14 | 5 | ||
| 29 | Les Wallace | 1 | 0 | ||
| 30 | Pat Bourke | 12 | 3 | ||
| 31 | Fred Long | 5 | 0 | ||
| 33 | Alex Ogilvy | 4 | 0 | ||
Seconds
Notes
Bill Lyte is shown as #27 in the Football Records of Round 3, Round 9 and Round 16.