Coach - Michael Stinear
Captains - Daisy Pearce
Finishing Position: 2nd (lost Grand Final)
Best and Fairest - Daisy Pearce
Leading Goalkicker - Tayla Harris (18)
Major Sponsors: Hertz/Zurich
| Opposition | Result | Score | |||
| Collingwood | WIN | 44-21 | |||
Premiership season
| Round | Opposition | Result | Score | ||
| 1 | Western Bulldogs | WIN | 46-22 | ||
| 2 | Richmond | WIN | 54-16 | ||
| 3 | St Kilda | WIN | 64-23 | ||
| 4 | Adelaide | LOSS | 21-35 | ||
| 5 | Gold Coast | WIN | 38-12 | ||
| 6 | Greater Western Sydney | WIN | 44-6 | ||
| 7 | Brisbane Lions | WIN | 35-32 | ||
| 8 | North Melbourne | WIN | 27-10 | ||
| 9 | Fremantle | WIN | 107-19 | ||
| 10 | Carlton | WIN | 34-33 | ||
| PF | Brisbane Lions | WIN | 33-29 | ||
| GF | Adelaide | LOSS | 16-29 | ||
Playing list
| Number | Player | Games | Goals | ||
| 1 | Georgia Campbell | 0 | 0 | ||
| 2 | Olivia Purcell | 6 | 0 | ||
| 3 | Maddie Gay | 7 | 1 | ||
| 4 | Karen Paxman | 12 | 4 | ||
| 5 | Tyla Hanks | 12 | 2 | ||
| 6 | Daisy Pearce | 12 | 13 | ||
| 7 | Tayla Harris | 12 | 18 | ||
| 8 | Sarah Lampard | 10 | 0 | ||
| 9 | Libby Birch | 12 | 0 | ||
| 10 | Kate Hore | 12 | 12 | ||
| 11 | Eliza West | 12 | 1 | ||
| 12 | Shelley Scott | 11 | 2 | ||
| 13 | Maeve Chaplin | 0 | 0 | ||
| 14 | Lily Mithen | 11 | 0 | ||
| 15 | Lauren Pearce | 12 | 2 | ||
| 16 | Alyssa Bannan | 12 | 12 | ||
| 17 | Tahlia Gillard | 3 | 0 | ||
| 18 | Casey Sherriff | 9 | 2 | ||
| 19 | Jacqueline Parry | 8 | 0 | ||
| 20 | Brenna Tarrant | 3 | 0 | ||
| 21 | Maggie Caris | 5 | 0 | ||
| 22 | Eliza McNamara | 11 | 2 | ||
| 23 | Sinead Goldrick | 11 | 0 | ||
| 24 | Megan Fitzsimon | 11 | 2 | ||
| 25 | Isabella Simmons | 0 | 0 | ||
| 26 | Lauren Magee | 4 | 0 | ||
| 28 | Ali Brown | 3 | 0 | ||
| 29 | Eden Zanker | 11 | 1 | ||
| 30 | Shelley Heath | 11 | 0 | ||
| 31 | Krstel Petrevski | 1 | 0 | ||
| 32 | Gabrielle Colvin | 9 | 0 | ||
| 33 | Jordan Zanchetta | 0 | 0 | ||
Ladder
| W | D | L | % | P | |
| Adelaide | 19 | 0 | 1 | 216.6 | 36 |
| Melbourne | 9 | 0 | 1 | 186.5 | 36 |
| Brisbane Lions | 8 | 0 | 2 | 196.8 | 32 |
| North Melbourne | 7 | 0 | 3 | 139.0 | 28 |
| Fremantle | 7 | 0 | 3 | 134.9 | 28 |
| Collingwood | 6 | 0 | 4 | 123.2 | 24 |
| Western Bulldogs | 4 | 1 | 5 | 95.2 | 18 |
| Carlton | 4 | 0 | 6 | 84.0 | 16 |
| Greater Western Sydney | 4 | 0 | 6 | 74.1 | 16 |
| Gold Coast | 3 | 1 | 6 | 68.2 | 14 |
| Richmond | 3 | 0 | 7 | 81.3 | 12 |
| Geelong | 2 | 0 | 8 | 80.4 | 8 |
| St Kilda | 2 | 0 | 8 | 53.1 | 8 |
| West Coast | 1 | 0 | 9 | 42.9 | 4 |
Club best and Fairest
| Player | Votes | ||||
| 1 | Daisy Pearce | 50 | |||
| 2 | Lauren Pearce | 49 | |||
| 3 | Tayla Harris | 48 | |||
| 3 | Tyla Hanks | 48 | |||
| 5 | Libby Birch | 47 | |||
| 5 | Lily Mithen | 47 | |||
| 5 | Karen Paxman | 47 | |||
| 8 | Alyssa Bannan | 44 | |||
| 9 | Sinead Goldrick | 43 | |||
| 10 | Eliza West | 42 | |||
Other award winner
Trademark player - Shelley Heath
AFL Best and Fairest
| Votes | |||||
| Tyla Hanks | 8 | ||||
| Karen Paxman Lauren Pearce | 7 | ||||
| Lily Mithen Daisy Pearce | 6 | ||||
| Kate Hore Karen Paxman | 4 | ||||
| Tayla Harris | 3 | ||||
| Alyssa Bannan Eliza West | 2 | ||||
Tribunal
| Round | Player | Charge | Sanction | ||
| Round 10 | Gabrielle Colvin | Dangerous tackle | $400 fine | ||
| Round 10 | Kate Hore | Rough conduct | $400 fine | ||
Coaching staff
Ben Brown - Ruck coach
Vincent Chungue - Opposition analysis
Justin Crough - Ruck coach
Tamara Hyett - Assistant coach
Jane Lange - Senior assistant coach/forward coach
Peter Mercoulia - Midfield coach
Brooke Patterson - Development coach/midfield coach
Shae Sloane - Development coach
Jon Stinear - Development coach/forward coach
Media
melbournefc.com.au - 03/11/2021
melbournefc.com.au - 12/04/2022