No Melbourne player has ever kicked 100 goals in a season, however, opposition players have brought up their 100th goal for the season against Melbourne.
This list may be incomplete.
| Player | Match | Ground | Result |
| Ron Todd | Round 18, 1938 | Victoria Park | LOSS |
| Ron Todd | 1939 Semi Final | MCG | WIN |
| Jack Titus | 1940 Grand Final | MCG | WIN |
| Alex Jesaulenko | Round 22, 1970 | MCG | LOSS |
| Michael Roach | Round 20, 1980 | MCG | LOSS |
| Peter Sumich | 1991 Semi Final | Waverley | LOSS |
| Jason Dunstall | Round 22, 1996 | MCG | LOSS |
| Tony Lockett | Round 21, 1998 | MCG | WIN |